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PIONEER 1: Daily oral semaglutide versus placebo in people with type 2 diabetes treated with diet and exercise alone PIONEER 2: Daily oral semaglutide versus empagliflozin 25 mg in people with type 2 diabetes PIONEER 3: Daily oral semaglutide versus sitagliptin 100 mg in people with type 2 diabetes PIONEER 4: Daily oral semaglutide versus liraglutide 1.8 mg in people with type 2 diabetes PIONEER 5: Daily oral semaglutide versus placebo in people with type 2 diabetes and moderate renal impairment PIONEER 6 PIONEER 7: Daily oral semaglutide using a flexible dose adjustment based on clinical evaluation versus sitagliptin 100 mg in people with type 2 diabetes PIONEER 8: Effects of daily oral semaglutide versus placebo in people with long duration of type II diabetes treated with insulin OF NOTE: PIONEER 9 and PIONEER 10 were Japanese studies and PIONEER 6 was a cardiovascular safety study

This increased usage has created challenges for some people with T2D who have struggled to access certain GLP-1 drugs, as reported by NPR in 2024